Novel formulations of taxanes: a review. Old wine in a new bottle?

نویسندگان

  • K L Hennenfent
  • R Govindan
چکیده

Over the past two decades, the taxanes have played a significant role in the treatment of various malignancies. However, the poor solubility of these compounds necessitates the inclusion of surfactant vehicles in their commercial formulations. Cremophor EL and polysorbate 80 have long comprised the standard solvent system for paclitaxel and docetaxel, respectively. A number of pharmacologic and biologic effects related to both of these drug formulations have been described, including clinically relevant acute hypersensitivity reactions and peripheral neuropathy. In addition, these solvents affect the disposition of intravenously administered solubilized drugs and leach plasticizers from polyvinylchloride infusion sets. A number of strategies to develop formulations of surfactant-free taxanes have been developed. They include albumin nanoparticles, polyglutamates, taxane analogs and prodrugs, emulsions, and lipsomes. An overview of these novel formulations of taxanes, their mechanisms of action, pharmacokinetics, dose and administration, adverse effects, and clinical efficacy will be discussed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fine quantitation of novel trace taxans in suspension-cultured Corylus avellana L. cells by photo diode array HPLC technique.

Taxanes are widely known as great family of antitumor compounds. Identification of certain taxanes, particularly taxol, has opened new perspectives for further researches in plant and medical sciences. The aim of the present study was to manipulate chromatographic method in order to detect and quantified novel trace taxanes in suspension-cultured hazel (Corylus avellana L.) cells. A rapid growi...

متن کامل

A Compositionalist’s Guide to Predicate-Reference

In this paper I develop and defend compositionalism—which is a view about the relationship between our language and the world it represents—and use it to argue for particular account of predicate-reference. Neither compositionalism nor the conception of predicate reference I will argue for are novel views. They have been discussed, in different forms, by Frege, Dummett, Wright and Rosen (amongs...

متن کامل

Old wine in a new bottle.

Bargaining with reading habit is no need. Reading is not kind of something sold that you can take or not. It is a thing that will change your life to life better. It is the thing that will give you many things around the world and this universe, in the real world and here after. As what will be given by this old wine in a new bottle, how can you bargain with the thing that has many benefits for...

متن کامل

Business Models for E-commerce: Old Wine in New Bottles?

While e-commerce is sprouting radical changes in intra-organizational structures and inter-organizational relationships, the underlying principles turn out to be less than novel. Rather, they reflect a revival of traditional values that prevailed well before the advent of mass production. From a customer's perspective, most “new” business models in the Information Age are indeed old wine in new...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Annals of oncology : official journal of the European Society for Medical Oncology

دوره 17 5  شماره 

صفحات  -

تاریخ انتشار 2006